
<!-- Only modify this file in folder "vignettes"! -->

---
output: rmarkdown::html_vignette
pagetitle: article
vignette: >
  %\VignetteIndexEntry{article frame}
  %\VignetteEngine{knitr::rmarkdown}
  %\VignetteEncoding{UTF-8}
---

Click [here](https://www.biomedcentral.com/content/pdf/s12859-016-0961-5.pdf) to download article.

<div>
<object data="https://www.biomedcentral.com/content/pdf/s12859-016-0961-5.pdf" type="application/pdf" width="100%" height="500px">
</object>
</div>