---
title: "BiocFileCache: Managing File Resources Across Sessions"
author: Lori Shepherd
output:
  BiocStyle::html_document:
    toc: true
    toc_depth: 2
vignette: >
    %\VignetteEngine{knitr::rmarkdown}
    %\VignetteIndexEntry{1. BiocFileCache Overview: Managing File Resources Across Sessions}
    %\VignetteEncoding{UTF-8}
    %\VignetteDepends{rtracklayer}
---

```{r setup, echo=FALSE}
knitr::opts_chunk$set(collapse=TRUE)
```

# Overview

Organization of files on a local machine can be cumbersome. This is especially
true for local copies of remote resources that may periodically require a new
download to have the most updated information available. [BiocFileCache][] is
designed to help manage local and remote resource files stored locally. It
provides a convenient location to organize files and once added to the cache
management, the package provides functions to determine if remote resources are
out of date and require a new download.

## Installation and Loading

`BiocFileCache` is a _Bioconductor_ package and can be installed through
`BiocManager::install()`.

```{r, eval = FALSE}
if (!"BiocManager" %in% rownames(installed.packages()))
     install.packages("BiocManager")
BiocManager::install("BiocFileCache", dependencies=TRUE)
```

After the package is installed, it can be loaded into _R_ workspace by

```{r, library, results='hide', warning=FALSE, message=FALSE}
library(BiocFileCache)
```

## Creating / Loading the Cache

The initial step to utilizing [BiocFileCache][] in managing files is to create a
cache object specifying a location. We will create a temporary directory for use
with examples in this vignette. If a path is not specified upon creation, the
default location is a directory `~/.BiocFileCache` in the typical user cache
directory as defined by `tools::R_user_dir("", which="cache")`.

```{r, create}
path <- tempfile()
bfc <- BiocFileCache(path, ask = FALSE)
```

If the path location exists and has been utilized to store files previously, the
previous object will be loaded with any files saved to the cache. If the path
location does not exist the user will be prompted to create the new directory.
If the session is not interactive to promt the user or the user decides not to
create the directory a temporary directory will be used.

Some utility functions to examine the cache are:

 * `bfccache(bfc)`
 * `length(bfc)`
 * `show(bfc)`
 * `bfcinfo(bfc)`

`bfccache()` will show the cache path. **NOTE**: Because we are using temporary
directories, your path location will be different than shown.

```{r, cacheloc}
bfccache(bfc)
length(bfc)
```

`length()` on a BiocFileCache will show the number of files currently being
tracked by the `BiocFileCache`. For more detailed information on what is store
in the `BiocFileCache` object, there is a show method which will display the
object, object class, cache path, and number of items currently being tracked.

```{r, bfcshow}
bfc
```

`bfcinfo()` will list a table of `BiocFileCache` resource files being tracked in
the cache. It returns a [dplyr][] object of class `tbl_sqlite`.

```{r, bfcinfo}
bfcinfo(bfc)
```

The table of resource files includes the following information:

 * `rid`: resource id. Autogenerated. This is a unique identifier automatically
   generated when a resource is added to the cache.
 * `rname`: resource name. This is given by the user when a resource is added to
   the cache. It does not have to be unique and can be updated at anytime. We
   recommend descriptive key words and identifiers.
 * `create_time`: The date and time a resource is added to the cache.
 * `access_time`: The date and time a resource is utilized within the cache. The
   access time is updated when the resource is updated or downloaded.
 * `rpath`: resource path. This is the path to the local file.
 * `rtype`: resource type. Either "local" or "web", indicating if the resource
   has a remote origin.
 * `fpath`: If rtype is "web", this is the link to the remote resource. It will
   be utilized to download the remote data.
 * `last_modified_time`: For a remote resource, the last_modified (if available)
   information for the local copy of the data. This information is checked
   against the remote resource to determine if the local copy is stale and needs
   to be updated. If it is not available or your resource is not a remote
   resource, the last modified time will be marked as NA.
 * `etag`: For a remote resource, the etag (if available) information for the
   local copy of the data. This information is checked against the remote
   resource to determine if the local copy is stale and needs to be updated. If
   it is not available or your resource is not a remote resource, the etag will
   be marked as NA.
 * `expires`: For a remote resource, the expires (if available) information for
   the local copy of the data. This information is checked against the
   `Sys.time` to determine if the local copy needs to be updated. If it is not
   available or your resource is not a remote resource, the expires will be
   marked as NA.

Now that we have created the cache object and location, let's explore adding
files that the cache will manage!

## Adding / Tracking Resources

Now that a `BiocFileCache` object and cache location has been created, files can
be added to the cache for tracking. There are two functions to add a resource to
the cache:

 * `bfcnew()`
 * `bfcadd()`

The difference between the options: `bfcnew()` creates an entry for a resource
and returns a filepath to save to. As there are many types of data that can be
saved in many different ways, `bfcnew()` allows you to save any _R_ data object
in the appropriate manner and still be able to track the saved file. `bfcadd()`
should be utilized when a file already exists or a remote resource is being
accessed.

`bfcnew` takes the `BiocFileCache` object and a user specified `rname` and
returns a path location to save data to. (optionally) you can add the file
extension if you know the type of file that will be saved:

```{r, bfcnew}
savepath <- bfcnew(bfc, "NewResource", ext=".RData")
savepath

## now we can use that path in any save function
m = matrix(1:12, nrow=3)
save(m, file=savepath)

## and that file will be tracked in the cache
bfcinfo(bfc)
```

`bfcadd()` is for existing files or remote resources.  The user will still
specify an `rname` of their choosing but also must specify a path to local file
or web resource as `fpath`. If no `fpath` is given, the default is to assume the
`rname` is also the path location. If the `fpath` is a local file, there are a
few options for the user determined by the `action` argument.  `action` will
allow the user to either `copy` the existing file into the cache directory,
`move` the existing file into the cache directory, or leave the file whereever
it is on the local system yet still track through the cache object `asis`. copy
and move will rename the file to the generated cache file path. If the `fpath`
is a remote source, the source will try to be downloaded, if it is successful it
will save in the cache location and track in the cache object; The original
source will be added to the cache information as `fpath`. If the user does not
want the remote resource to be downloaded initially, the argument
`download=FALSE` may be used to delay the download but add the resource to the
cache. Relative path locations may also be used, specified with
`rtype = "relative"`. This will store a relative location for the file within
the cache; only actions `copy` and `move` are available for relative paths.

First let's use local files:

```{r, bfcadd}
fl1 <- tempfile(); file.create(fl1)
add2 <- bfcadd(bfc, "Test_addCopy", fl1)                 # copy
# returns filepath being tracked in cache
add2
# the name is the unique rid in the cache
rid2 <- names(add2)

fl2 <- tempfile(); file.create(fl2)
add3 <- bfcadd(bfc, "Test2_addMove", fl2, action="move") # move
rid3 <- names(add3)

fl3 <- tempfile(); file.create(fl3)
add4 <- bfcadd(bfc, "Test3_addAsis", fl3, rtype="local",
	       action="asis") # reference
rid4 <- names(add4)

file.exists(fl1)    # TRUE - copied from original location
file.exists(fl2)    # FALSE - moved from original location
file.exists(fl3)    # TRUE - left asis, original location tracked
```

Now let's add some examples with remote sources:

```{r, bfcaddremote}
url <- "https://httpbin.org/get"
add5 <- bfcadd(bfc, "TestWeb", fpath=url)
rid5 <- names(add5)

url2<- "https://bioconductor.org/packages/stats/bioc/BiocFileCache/BiocFileCache_2024_stats.tab"
add6 <- bfcadd(bfc, "TestWeb", fpath=url2)
rid6 <- names(add6)

# add a remote resource but don't initially download
add7 <- bfcadd(bfc, "TestNoDweb", fpath=url2, download=FALSE)
rid7 <- names(add7)
# let's look at our BiocFileCache object now
bfc
bfcinfo(bfc)
```

Now that we are tracking resources, let's explore accessing their information!

### Caveat

Files will by default have a unique identifier added to the start of the
original file name (identifier_originalName) when added to the cache to allow
for multiple versions of the same file name. There is an option to override this
default behavior by using the `fname` argument of `bfcadd` or `bfcnew`. `fname`
takes one of two options: `unique` or `exact`. The `unique` option behaves as
default and adds a unique identifier to the original file name. The `exact`
option wil override and not add a unique identifier and an exact match to the
original file name will be added.


## Investigating / Accessing Resources

Before we get into exploring individual resources, a helper function.  Most of
the functions provided require the unique rid[s] assigned to a resource. The
`bfcadd` and `bfcnew` return the path as a named character vector, the name of
the character vector is the rid.  However, you may want to access a resource
that you have added some time ago.

 * `bfcquery()`

`bfcquery()` will take in a key word and search across the `rname`, `rpath`, and
`fpath` for any matching entries. The columns that are searched can be
controlled with the argument `field`.

```{r, bfcquery}
bfcquery(bfc, "Web")

bfcquery(bfc, "copy")

q1 <- bfcquery(bfc, "BiocFileCache")
q1
class(q1)
```

As you can see above `bfcquery()`, returns an object of class `tbl_sql` and can
be investiaged further utilizing methods for these classes, such as the package
`dplyr` methods. The `rid` can be seen in the first column of the table to be
used in other functions. To get a quick count of how many objects in the cache
matched the query, use `bfccount()`.

```{r, bfccount}
bfccount(q1)
```

 * `[`

`[` allows for subsetting of the BiocFileCache object.  The output will be a
BiocFileSubCache object. Users will still be able to query, remove (from the
subset object only), and access resources of the subset, however the resources
cannot be updated.

```{r, bfcsubset}
bfcsubWeb = bfc[paste0("BFC", 5:6)]
bfcsubWeb
bfcinfo(bfcsubWeb)
```

There are three methods for retrieving the `BiocFileCache` resource path
location.

 * `[[`
 * `bfcpath()`
 * `bfcrpath()`

The `[[` will access the `rpath` saved in the `BiocFileCache`. Retrieving this
location will return the path to the local version of the resource; allowing the
user to then use this path in any load/read methods most appropriate for the
resource. The `bfcpath()` and `bfcrpath()` both return a named character vector
also displaying the local file that can be used for retrieval. `bfcpath`
requires `rids` while `bfcrpath()` can use `rids` or `rnames` (but not
both). `bfcrpath()` can be used to add a resource into the cache when `rnames`
are specified; if the element in `rnames` is not found, it will try and add to
the cache with `bfcadd()`.


```{r, bfcbracket}
bfc[["BFC2"]]
bfcpath(bfc, "BFC2")
bfcpath(bfc, "BFC5")
bfcrpath(bfc, rids="BFC5")
bfcrpath(bfc)
bfcrpath(bfc, c("https://httpbin.org/get","Test3_addAsis"))
```

Managing remote resources locally involves knowing when to update the local copy
of the data.

 * `bfcneedsupdate()`

`bfcneedsupdate()` is a method that will check the local copy of the data's
etag and last_modifed time to the etag and last_modified time of the remote
resource as well as an expires time. The cache saves this information when the
web resource is initially added. The expires time is checked against the current
Sys.time to see if the local resource has expired. If so the resource will deem
need to be updated; if unavailable or not expired will check the etag and
last_modified_time. The etag information is used definitively if it is
available, if it is not available it checks the last_modified time. If the
resource does not have a last_modified tag either, it is undetermined. If the
resource has not been download yet, it is `TRUE`.

**Note:** This function does not automatically download the remote source if it
  is out of date.  Please see `bfcdownload()`.

```{r, bfcneedsupdate}
bfcneedsupdate(bfc, "BFC5")
bfcneedsupdate(bfc, "BFC6")
bfcneedsupdate(bfc)
```

## Updating Resource Entries or Local Copy of Remote Data

Just as you could access the `rpath`, the local resource path can be set with

 * `[[<-`

The file must exist in order to be replaced in the `BiocFileCache`. If the user
wishes to rename, they must make a copy (or touch) the file first.

```{r, bfcrename}
fileBeingReplaced <- bfc[[rid3]]
fileBeingReplaced

# fl3 was created when we were adding resources
fl3

bfc[[rid3]]<-fl3
bfc[[rid3]]
```

The user may also wish to change the `rname` or `fpath` associated with a
resource in addition to the `rpath`. This can be done with

 * `bfcupdate()`

Again, if changing the `rpath` the file must exist. If a `fpath` is being
updated, the data will be downloaded and the user will be prompted to overwrite
the current file specified in `rpath`. If the user does not want to be prompted
about overwritting of files, `ask=FALSE` may be used.

```{r, bfcupdate}
bfcinfo(bfc, "BFC1")
bfcupdate(bfc, "BFC1", rname="FirstEntry")
bfcinfo(bfc, "BFC1")
```

Now let's update a web resource

```{r, bfcupdateremote}
suppressPackageStartupMessages({
    library(dplyr)
})
bfcinfo(bfc, "BFC6") %>% select(rid, rpath, fpath)
bfcupdate(bfc, "BFC6", fpath=url, rname="Duplicate", ask=FALSE)
bfcinfo(bfc, "BFC6") %>% select(rid, rpath, fpath)
```

Lastly, remote resources may require an update if the Data is out of date (See
`bfcneedsupdate()`).  The `bfcdownload` function will attempt to download from
the original resource saved in the cache as `fpath` and overwrite the out of
date file `rpath`

 * `bfcdownload()`

The following confirms that resources need updating, and the performs the update

```{r, bfcdownload}
rid <- "BFC5"
test <- !identical(bfcneedsupdate(bfc, rid), FALSE) # 'TRUE' or 'NA'
if (test) 
    tryCatch({
        bfcdownload(bfc, rid, ask=FALSE)
    }, error = function(e) {
        message("Error downloading resource: ", conditionMessage(e))
    })
```

## Adding MetaData

The following functions are provided for metadata:

 * `bfcmeta()<-`
 * `bfcmeta()`
 * `bfcmetalist()`
 * `bfcmetaremove()`

Additional metadata can be added as `data.frames` that become tables in the sql
database. The `data.frame` must contain a column `rid` that matches the `rid`
column in the cache. Any metadata added will then be displayed when accessing
the cache. Metadata is added with `bfcmeta()<-`. A table `name` must be provided
as an argument. Users can add multiple metadata tables as long as the names are
unique. Tables may be appended or overwritten using additional arguments
`append=TRUE` or `overwrite=TRUE`.

```{r, bfcmetadata}
names(bfcinfo(bfc))
meta <- as.data.frame(list(rid=bfcrid(bfc)[1:3], idx=1:3))
bfcmeta(bfc, name="resourceData") <- meta
names(bfcinfo(bfc))
```
The metadata tables that exist can be listed with `bfcmetalist()` and can be
retrieved with `bfcmeta()`.

```{r, bfcmetalist}
bfcmetalist(bfc)
bfcmeta(bfc, name="resourceData")
```

Lastly, metadata can be removed with `bfcmetaremove()`.

```{r, bfcmetaremove}
bfcmetaremove(bfc, name="resourceData")
```

**Note:**

While quick implementations of all the functions exist where if you
don't specify a BiocFileCache object it will operate on `BiocFileCache()`,
this option is not available for `bfcmeta()<-`. This function must always
specify a BiocFileCache object by first defining a variable and then passing
that variable into the function.

Example of ERROR:
```{r eval=FALSE}
bfcmeta(name="resourceData") <- meta
Error in bfcmeta(name = "resourceData") <- meta :
  target of assignment expands to non-language object
```
Correct implementation:
```{r eval=FALSE}
bfc <- BiocFileCache()
bfcmeta(bfc, name="resourceData") <- meta
```
All other functions have a default, if the BiocFileCache object is missing it
will operate on the default cache `BiocFileCache()`.

## Removing Resources

Now that we have added resources, it is also possible to remove a resource.

 * `bfcremove()`

When you remove a resource from the cache, it will also delete the local file
but only if it is stored in the cache directory as given by `bfccache(bfc)`. If
it is a path to a file somewhere else on the user system, it will only be
removed from the `BiocFileCache` object but the file not deleted.

```{r, bfcremove}
# let's remind ourselves of our object
bfc

bfcremove(bfc, "BFC6")
bfcremove(bfc, "BFC1")

# let's look at our BiocFileCache object now
bfc
```

There is another helper function that may be of use:

 * `bfcsync()`

This function will compare two things:

 1. If any `rpath` cannot be found (This would occur if `bfcnew()` is used and
    the path was not used to save an object)
 2. If there are files in the cache directory (`bfccache(bfc)`), that are not
    being tracked by the `BiocFileCache` object

```{r, bfcsync}
# create a new entry that hasn't been used
path <- bfcnew(bfc, "UseMe")
rmMe <- names(path)
# We also have a file not being tracked because we updated rpath

bfcsync(bfc)

# you can suppress the messages and just have a TRUE/FALSE
bfcsync(bfc, FALSE)

#
# Let's do some cleaning to have a synced object
#
bfcremove(bfc, rmMe)
unlink(fileBeingReplaced)

bfcsync(bfc)
```

## Exporting and Importing Cache

There is a helper function to export a BiocFileCache and associated files as a
tar or zip archive as well as the appropriate import function.

 * `exportbfc()`
 * `importbfc()`

The `exportbfc` function will take in a BiocFileCache object or subsetted object
and create a tar or zip archive that can then be shared to other collaborators
on different computer systems. The user can choose where the archive is created
with `outputFile`; the current working directory and the name
`BiocFileCacheExport.tar` is used as default. By default a tar archive is
created, but the user can create a zip archive instead using the argument
`outputMethod="zip"`. Any additional argument to the `utils::zip` or
`utils::tar` may also be utilized.

The following are some example calls:
```{r eval=FALSE}
# export entire biocfilecache
exportbfc(bfc)

# export the first 4 entries of biocfilecache
# as a compressed tar
exportbfc(bfc, rids=paste0("BFC", 1:4),
	  outputFile="BiocFileCacheExport.tar.gz", compression="gzip")

# export the subsetted object of web resources as zip
sub1 <- bfc[bfcrid(bfcquery(bfc, "web", field='rtype'))]
exportbfc(sub1, outputFile = "BiocFileCacheExportWeb.zip",
	  outMethod="zip")
```

The archive once inflated on a users system will have a fully functional copy of
the sent cache. The archive can be extracted manually and the path used in the
constructor `BiocFileCache()` or for convenience the function `importbfc` may be
utilized. The `importbfc` function takes in a path to the appropriate tar or zip
file, the argument `archiveMethod` indicating if `untar` or `unzip` should be
used (the default is untar), a path to where the archive should be extracted to
as `exdir`, and any additional arguments to the `utils::untar` and
`utils::unzip` methods. The function will extract the files and load the
associated BiocFileCache object into the R session.

The following are example calls to load the above example exported objects:
```{r eval=FALSE}

bfc <- importbfc("BiocFileCacheExport.tar")

bfc2 <- importbfc("BiocFileCacheExport.tar.gz", compression="gzip")

bfc3 <- importbfc("BiocFileCacheExportWeb.zip", archiveMethod="unzip")
```

## Creating a Cache from Existing Data

There exists the following helper functions to convert existing data to a
BiocFileCache:

 * `makeBiocFileCacheFromDataFrame`

These functions may take awhile to run if there are a lot of resources, however
if the BiocFileCache is stored in a permanent location it will only need to be
run once.

### Create a BiocFileCache from an Existing data.frame

`makeBiocFileCacheFromDataFrame` takes an existing data.frame and creates a
BiocFileCache object. The cache location can be specified by the `cache`
argument. The `cache` must not already exist and the user will be prompted to
create the location. If the user opts 'N', the cache will be created in a
temporary directory and this function will have to be run again upon a new R
session. The original data.frame must contain the required BiocFileCache columns
`rtype`, `rpath`, and `fpath` as described in the section 1.2 "Creating /
Loading the Cache". The optional columns `rname`, `last_modified_time`, `etag`
and `expires` may also be specified in the original data.frame although are not
required and will be populated with defaults if missing. For resources with
`rtype="local"`, the `actionLocal` will control if the local copy of the file is
copied or moved to the cache location, or if it is left asis on the local
system; A local copy of the file must exist if the resource is identified as
`rtype=local`. For resources with `rtype="web"`, `actionWeb` will control if the
local copy of the remote file is copied or moved to the cache location. It is a
requirement of BiocFileCache that all remote resources download their local copy
to the cache location. A local copy of the file does not have to exist and can
be downloaded into the cache at a later time. Any additional columns of the
original data.frame besides those required or optional BiocFileCache columns,
are separated and added to the BiocFileCache as a meta data table with the name
given as `metadataName`. See section 1.6 on "Adding Metadata".

The following is an example data.frame with minimal columns 'rtype', 'rpath',
and 'fpath' and one additional column that will become metadata 'keywords'. The
'rpath' can be `NA` as these are remote resources (`rtype='web'`) that have not
been downloaded yet.

```{r, mock}
tbl <- data.frame(rtype=c("web","web"),
		      rpath=c(NA_character_,NA_character_),
		  fpath=c("https://httpbin.org/get",
			  "https://en.wikipedia.org/wiki/Bioconductor"),
		      keywords = c("httpbin", "wiki"), stringsAsFactors=FALSE)
tbl
```

```{r eval=FALSE}

newbfc <- makeBiocFileCacheFromDataFrame(tbl,
					 cache=file.path(tempdir(),"BFC"),
					 actionWeb="copy",
					 actionLocal="copy",
					 metadataName="resourceMetadata")

```

## Cleaning or Removing Cache

Finally, there are two function involved with cleaning or deleting the cache:

 * `cleanbfc()`
 * `removebfc()`

`cleanbfc()` will evaluate the resources in the `BiocFileCache` object and
determine which, if any, have not been created, redownloaded, or updated in a
specified number of days. If `ask=TRUE`, each entry that is above that threshold
will ask if it should be removed from the cache object and the file deleted
(only deleted if in `bfccache(bfc)` location). If `ask=FALSE`, it does not ask
about each file and automatically removes and deletes the file. The default
number of days is 120. If a resource has not needed any updates, this function
could give a false positive. It is also does not take into account how many time
the resource was loaded by retrieving the path (ie. via [[, bfcpath, bfcrpath),
so may not be an accurate indication of how often the resource is
utilized. Please use this function with caution.

```{r eval=FALSE}
cleanbfc(bfc)
```

`removebfc()` will remove the `BiocFileCache` complete from the system. Any
files saved in `bfccache(bfc)` directory will also be deleted.

```{r eval=FALSE}
removebfc(bfc)
```
**Note** Use with caution!

# Access Behind a Proxy

BiocFileCache uses CRAN package `httr2` functions for accessing and downloading
web resources. This can be problematic if operating behind a
proxy. Unfortunately unlike the previously used `httr::set_config`, there is no
option to globally set the proxy for httr2 requests. You can pass proxy
information into the bfcadd, bfcupdate, bfcneedsupdate, and bfcdownload
functions.

```{r eval=FALSE}
proxy <- "http://my_user:my_password@myproxy:8080"
bfcadd(bfc, rname="uniquename", fpath="https://remoteresource", proxy=proxy)
```
You can also set a `https_proxy` environment variable. It should be a character
vector similar to the format above.  

# Other configuration options for resource downloading

As mentioned previously, There is no global option like `httr::set_config` to
set configuration options when using httr2. A `config` argument may be passed to
bfcadd, bfcupdate, bfcneedsupdate, and bfcdownload functions. This argument is a
R list object that will be passed to `httr2::req_options`. The names of the
items should be valid curl options as defined in `curl::curl_options`.

```{r eval=FALSE}
ssl_opts <- list(verbose = 1L,ssl_verifypeer = 0L, ssl_verifyhost = 0L)
bfcadd(bfc, rname="uniquename", fpath="https://remoteresource", config=ssl_opts)
```
# Group Cache Access

The situation may occur where a cache is desired to be shared across multiple
users on a system.  This presents permissions errors.  To allow access to
multiple users create a group that the users belong to and that the cache
belongs too. Permissions of potentially two files need to be altered depending
on what you would like individuals to be able to accomplish with the cache. A
read-only cache will require manual manipulatios of the
BiocFileCache.sqlite.LOCK so that the group permissions are `g+rw`. To allow
users to download files to the shared cache, both the
BiocFileCache.sqlite.LOCK file and the BiocFileCache.sqlite file will need group
permissions to `g+rw`. Please google how to create a user group for your system
of interest. To find the location of the cache to be able to change the group
and file permissions, you may run the following in R if you used the default location:
`tools::R_user_dir("BiocFileCache", which="cache")` or if you created a unique
location, something like the following: `bfc =
BiocFileCache(cache="someUniquelocation"); bfccache(bfc)`. For quick reference
in linux you will use `chown currentuser:newgroup` to change the group and
`chmod` to change the file permissions: `chmod 660` or `chmod g+rw` should
accomplish the correct permissions.

# Summary

It is our hope that this package allows for easier management of local and
remote resources.

# SessionInfo

```{r, sessioninfo}
sessionInfo()

```



[BiocFileCache]: https://bioconductor.org/packages/BiocFileCache
[dplyr]: https://cran.r-project.org/package=dplyr
